European Protein Degradation Congress 2020 | Kisaco Research

Progressing translation of protein degradation probes into safe, effective therapeutics.

Register
Virtual Congress | CEST Timezone
28-30 September, 2020

“This event gathered the world leaders in the protein degradation field. I thoroughly enjoyed the opportunity to get up to date on the latest approaches used by both pharma companies and academics. The setup also allowed a great opportunity to network. I will definitely be back!””

Frantz Jean-Francois, NIH

“A lot of data on PROTAC research has been disclosed on this event. And also many leaders in PROTAC shared their experience and concerns about PROTAC development. Many start up companies also delivered their progress. We can discuss future PROTAC directions as well as difficulties with experts from both industry and the academic area, and learned a lot. ”

Yuqing Huang - CFO, Kintor

WE'RE GOING DIGITAL!

Kisaco Research is committed to providing attendees across all of our events with the best possible experience, it’s for this reason we’ve decided to go digital and embrace the amazing new technology that enables us to deliver a virtual event.

Why Attend

With deals in the protein degradation market reaching nearly $2 billion and unique degradation ideas coming into play such as LYTACs and ENDTACs, eyes are focused on how much further protein degradation-based therapeutics will continue to grow
within the pharmaceutical industry.

Following huge success in May 2019, the 2nd European Protein Degradation Congress, returns to Switzerland 28th-30th September 2020, where you can hear the most up to date and relevant information for the broad range of topics in the field of targeted
protein degradation.

New areas will cover novel methods in harnessing E3 ligases and the latest discoveries from PROTACs and molecular glues with preclinical and clinical data being shown.

Leading industry players from biotechs and big pharma will come together to exchange thoughts on how to best overcome obstacles to achieving reliable in vitro and in vivo data. Academic experts will be present their latest research to help build a deeper understanding of the mechanisms involved in the Ubiquitin pathway, providing a clearer picture on what makes a good, or not good, target for degradation.

200+
Attendees
24+
Leading Speakers
2
Days of sharing the latest developments

Poster Submission 2020

Looking to showcase your recent work to the protein degradation community?

Our dedicated poster session is the perfect way to get your research noticed. In order to present a poster at the forum you need to be registered as a delegate. Please note that there is limited space available and poster space is assigned on a first come first served basis (subject to checks and successful registration). At the congress, your presentation will be displayed in a dedicated poster area. The poster presentation session will take place at the afternoon networking break on day one.

Poster abstract submission deadline is on 17 August 2020. Posters should be sized A0 (841mm x 1189mm) in portrait orientation.

Abstracts received after this time may not be accepted so please submit your abstract as soon as possible!

If you have any questions please contact [email protected] 

SUBMIT YOUR POSTER HERE

Previous Attendees Include

highlights from 2019

Protein degradation Congress

Talk to our speakers about...

1. How to exploit protein homeostasis to identify new proteins for degradation

2. How to find new E3 ligase recruiters

3. What does the next generation of targeted protein degradation products look like?

4. How can chemo-proteomics be used to make the ‘undruggable’ druggable?

5. Structural-based design of PROTAC through crystallography techniques

6. Furthering our understanding of the ubiquitin space.

7. New synthetic molecular glue approaches from auxin scaffolds

8. How mechanistic understanding of the DUBs space is applicable to targeted protein degradation

9. How well do PROTACs work in clinical application – insights into the first human trial

10. Key medicinal chemical considerations for moving from a PROTAC/molecular glue probe to drug

Audience Breakdown

What attendees say

Speakers

 

Nico Thoma

Senior Group Leader
Friedrich Miescher Institute for Biomedical Research

Nico Thoma

Senior Group Leader
Friedrich Miescher Institute for Biomedical Research

Nico Thoma

Senior Group Leader
Friedrich Miescher Institute for Biomedical Research
 

Phil Chamberlain

Executive Director of Protein Homeostasis and Structural Biology
Bristol-Myers Squibb

Phil Chamberlain

Executive Director of Protein Homeostasis and Structural Biology
Bristol-Myers Squibb

Phil Chamberlain

Executive Director of Protein Homeostasis and Structural Biology
Bristol-Myers Squibb
 

Alfred Goldberg

Professor
Harvard Medical School

Alfred Goldberg

Professor
Harvard Medical School

Alfred Goldberg

Professor
Harvard Medical School
 

Claudio Joazeiro

ZMBH Research Group Leader
University of Heidelberg

Broadly we are interested in the E3 ubiquitin ligases –their biological functions, mechanism of action, and roles in disease. For the past few years, we have focused on the problem of how cells know when its proteins are aberrant or damaged, and then decide on ways to either correct or eliminate them. Protein quality control is critical to ensure proteome integrity and cellular fitness; further underscoring its relevance, defective protein quality control is a hallmark of neurodegenerative diseases.

Claudio Joazeiro

ZMBH Research Group Leader
University of Heidelberg

Claudio Joazeiro

ZMBH Research Group Leader
University of Heidelberg

Broadly we are interested in the E3 ubiquitin ligases –their biological functions, mechanism of action, and roles in disease. For the past few years, we have focused on the problem of how cells know when its proteins are aberrant or damaged, and then decide on ways to either correct or eliminate them. Protein quality control is critical to ensure proteome integrity and cellular fitness; further underscoring its relevance, defective protein quality control is a hallmark of neurodegenerative diseases.

In eukaryotic organisms, key factors conferring specificity to protein quality control are molecular chaperones and E3 ligases. We have recently discovered a novel protein quality control mechanism mediated by an E3 ligase, Listerin/Ltn1, and which takes place on ribosomes. We now know that Listerin functions as a subunit of the Ribosome-Associated Quality Control (RQC) complex, which is conserved from yeast to humans. Of relevance, Listerin mutation causes motor neuron degeneration in mice.

We employ diverse model systems and approaches to elucidate how RQC-mediated quality control occurs at the cellular and molecular levels, including biochemistry, yeast genetics, cell biology, mouse models of neurodegeneration, and structural biology. We also analyze patients’ genomes to identify mutations that affect protein quality control; these studies are leading to insights onto the molecular basis of Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases, and to potential therapeutic targets.

In addition to the projects on Listerin, we have been working to elucidate the functions and mechanisms of the mitochondria-anchored E3 ligase, MULAN/MUL1, and to develop small molecule inhibitors of E3 ligases that can be used as oncology therapeutics.

 

Gwenn Hansen

Vice President of Drug Discovery Technologies
Nurix Therapeutics

Gwenn is Vice President of Drug Discovery Technologies at Nurix Therapeutics, a company focused on discovering and developing next-generation therapies that target protein homeostasis through modulation of the ubiquitin proteasome system. Since joining Nurix in January of 2016, Gwenn has focused on establishing the company’s DNA encoded library technology platform for small molecule discovery, and now leads teams of scientists in both early discovery as well as medicinal chemistry.

Gwenn Hansen

Vice President of Drug Discovery Technologies
Nurix Therapeutics

Gwenn Hansen

Vice President of Drug Discovery Technologies
Nurix Therapeutics

Gwenn is Vice President of Drug Discovery Technologies at Nurix Therapeutics, a company focused on discovering and developing next-generation therapies that target protein homeostasis through modulation of the ubiquitin proteasome system. Since joining Nurix in January of 2016, Gwenn has focused on establishing the company’s DNA encoded library technology platform for small molecule discovery, and now leads teams of scientists in both early discovery as well as medicinal chemistry. Prior to joining Nurix, Gwenn spent one year as an Associate Professor in the Center for Drug Discovery at Baylor College of Medicine and over 13 years in a variety of discovery-focused roles at Lexicon Pharmaceuticals, both located in Houston, Texas.  Gwenn received her PhD in Biomedical Sciences from Oak Ridge National Laboratory in 1998 and completed postdoctoral training at MD Anderson Cancer Center. 

 

Manfred Koegl

Director of Oncology Research
Boehringer Ingelheim

I am a director in Oncology Research at Boehringer Ingelheim in Vienna, working on the discovery and implementation of new therapeutic concepts in cancer. The main focus of my team are novel approaches for cancer cell targeting by small molecule drugs.

Manfred Koegl

Director of Oncology Research
Boehringer Ingelheim

Manfred Koegl

Director of Oncology Research
Boehringer Ingelheim

I am a director in Oncology Research at Boehringer Ingelheim in Vienna, working on the discovery and implementation of new therapeutic concepts in cancer. The main focus of my team are novel approaches for cancer cell targeting by small molecule drugs.

 

Andreas Martin

Associate Professor of Biochemistry, Biophysics and Structural Biology
University of California

Andreas Martin

Associate Professor of Biochemistry, Biophysics and Structural Biology
University of California

Andreas Martin

Associate Professor of Biochemistry, Biophysics and Structural Biology
University of California
 

Marjeta Urh

Director of Research
Promega

My role as Director in R&D at Promega is to develop novel technologies and research tools for analysis of nucleic acids and protein function. The breadth of technologies developed in my group span mass spectrometry, novel immunoassays, analysis of protein-protein and protein-small molecule interactions and targeted protein degradation. In addition, my group is involved in developing applications of Promega core technologies such as HaloTag, NanoBRET, NanoBiT and HiBiT technologies.

Marjeta Urh

Director of Research
Promega

Marjeta Urh

Director of Research
Promega

My role as Director in R&D at Promega is to develop novel technologies and research tools for analysis of nucleic acids and protein function. The breadth of technologies developed in my group span mass spectrometry, novel immunoassays, analysis of protein-protein and protein-small molecule interactions and targeted protein degradation. In addition, my group is involved in developing applications of Promega core technologies such as HaloTag, NanoBRET, NanoBiT and HiBiT technologies.

 

Markus Quessier

Scientific Leader
GSK

Markus Quessier

Scientific Leader
GSK

Markus Quessier

Scientific Leader
GSK
 

Radoslaw Nowak

Research Fellow
Dana-Farber Cancer Institute

Radoslaw Nowak

Research Fellow
Dana-Farber Cancer Institute

Radoslaw Nowak

Research Fellow
Dana-Farber Cancer Institute
 

Laura Itzhaki

Professor of Structural Pharmacology
University of Cambridge

Laura Itzhaki

Professor of Structural Pharmacology
University of Cambridge

Laura Itzhaki

Professor of Structural Pharmacology
University of Cambridge
 

Xavier Lucas

Computer-assisted Drug Design Scientist
Roche

Xavier Lucas

Computer-assisted Drug Design Scientist
Roche

Xavier Lucas

Computer-assisted Drug Design Scientist
Roche
 

Cristina Mayor-Ruiz

Post Doc Fellow
Georg Winter Lab

Cristina Mayor-Ruiz

Post Doc Fellow
Georg Winter Lab

Cristina Mayor-Ruiz

Post Doc Fellow
Georg Winter Lab
 

Markus Muellner

CTO
Phoremost

Markus Muellner

CTO
Phoremost

Markus Muellner

CTO
Phoremost
 

Olivier Coux

Team Leader
Montepellier Cell Biology Research Centre

Olivier Coux

Team Leader
Montepellier Cell Biology Research Centre

Olivier Coux

Team Leader
Montepellier Cell Biology Research Centre
 

Michal Walczak

CSO
Captor Therapeutics

Michal Walczak

CSO
Captor Therapeutics

Michal Walczak

CSO
Captor Therapeutics
 

Sharon Townson

Exceutive Director, Head of Platform Biology
Kymera

Sharon Townson

Exceutive Director, Head of Platform Biology
Kymera

Sharon Townson

Exceutive Director, Head of Platform Biology
Kymera
 

Boxun Lu

Professor
Fudan University

Boxun Lu

Professor
Fudan University

Boxun Lu

Professor
Fudan University
 

Helena Danielson

Professor of Biochemistry and Consultant
Upssala University and Beatica AB

Helena Danielson

Professor of Biochemistry and Consultant
Upssala University and Beatica AB

Helena Danielson

Professor of Biochemistry and Consultant
Upssala University and Beatica AB
 

Frank Mercurio

CSO
BioTheryX

Frank Mercurio

CSO
BioTheryX

Frank Mercurio

CSO
BioTheryX
 

Gopal Sapkota

Programme Leader in Protein Phosphorylation
University of Dundee

Gopal Sapkota

Programme Leader in Protein Phosphorylation
University of Dundee

Gopal Sapkota

Programme Leader in Protein Phosphorylation
University of Dundee
 

Zhengnian Li

PhD, Post-Doctoral Fellow, Laboratory of Dr. Nathanael Gray
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School

Zhengnian Li

PhD, Post-Doctoral Fellow, Laboratory of Dr. Nathanael Gray
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School

Zhengnian Li

PhD, Post-Doctoral Fellow, Laboratory of Dr. Nathanael Gray
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School
 

Andy Pike

Senior DMPK Lead
AstraZeneca

Andy Pike

Senior DMPK Lead
AstraZeneca

Andy Pike

Senior DMPK Lead
AstraZeneca
 

Simon Bailey

Executive Vice President, Head of Discovery and EVP Chemistry
Plexium

Simon Bailey

Executive Vice President, Head of Discovery and EVP Chemistry
Plexium

Simon Bailey

Executive Vice President, Head of Discovery and EVP Chemistry
Plexium
 

Matthias Wittwer

PDM Project Leader
Roche

Matthias Wittwer

PDM Project Leader
Roche

Matthias Wittwer

PDM Project Leader
Roche
 

Willem Nissink

Associate Principle Scientist
AstraZeneca

Willem Nissink

Associate Principle Scientist
AstraZeneca

Willem Nissink

Associate Principle Scientist
AstraZeneca

Expertise Partners

Event Partners

The Agenda

 Please complete the from to receive the full agenda for 2020, including information about the key topics being covered, speakers, and why you should attend.

What you can expect from the 2020 congress:

  • 200+ participants from leading industry players within big pharma and biotech along with expert academics in the ubiquitin space.
  • An open forum to share the latest in vivo and in vitro data and insights and foster collaboration. 
  • 18+ thought leaders on the speaking agenda and ready to answer your big questions on overcoming translational hurdles.

  • 3 days of progressing translation of protein degradation probes into safe, effective therapeutics.

Download Agenda

Become a Sponsor

Kisaco Research provides the much-needed platform on which industry executives can network, connect and learn from each other as well as meet potential industry partners.

Far from the typical ‘meet-and-greet’ exhibition experience, you – as a sponsor or exhibitor – will be positioned as a partner of the event with a focus on the benefits of your product and brand, rather than just a name on an exhibition list.

With our extensive marketing experience and strategy, your partnership with Kisaco Research will grant you a sponsorship package that is an extension and enhancement of your current marketing and branding efforts. We value your ROI and will work with you directly on your specific goals and targets – that’s why we take special care in finding the most relevant end-users to attend, so that your financial and resource investment is smartly allocated.

Find out more by calling us at +44 (0)20 3696 2920 or email us at [email protected].

Conference Packages

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If you would like to register a team of 3 or more, please email [email protected] for your discount coupon code before registering. PLEASE NOTE: Discounts cannot be combined with Early Bird Pricing or any other discount or offer. If you have any questions about your registration, please call us on +44 (0)20 3696 2920

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Saturday, August 8, 2020 to Wednesday, September 30, 2020
Academic
€999 + VAT
Standard pricing
Must be a full time academic or healthcare professional
2 day conference pass
Refreshments, breakfast & lunch
Networking opportunities
To increase your brand presence, contact Chris Stefanov, [email protected]
Buy 1 pass, get a second pass for free
Saturday, August 8, 2020 to Wednesday, September 30, 2020
Emerging Biotech
€1499 + VAT
Standard pricing
Emerging/spin out biotechs within the last 2 years
2 day conference pass
Refreshments, breakfast & lunch
Networking opportunities
To increase your brand presence, contact Chris Stefanov, [email protected]
Buy 1 pass, get a second pass for free
Saturday, August 8, 2020 to Wednesday, September 30, 2020
Biotech + Pharma
€1699 + VAT
Standard pricing
Must have an active drug pipeline
2 day conference pass
Refreshments, breakfast & lunch
Networking opportunities
To increase your brand presence, contact Chris Stefanov, [email protected]
Buy 1 pass, get a second pass for free
Saturday, August 8, 2020 to Wednesday, September 30, 2020
Service Providers
€2199 + VAT
Standard pricing
2 day conference pass
Refreshments, breakfast & lunch
Networking opportunities
To increase your brand presence, contact Chris Stefanov, [email protected]
Buy 1 pass, get a second pass for free
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